the missing piece



What is it?

Human Foreskin (HuFo) Anatomy: 
Four Distinct Structures

The human foreskin is a specialized bi-layer tissue.
If it were unfolded to lie flat, it would take up 14 square inches (90 square cm) and have a butterfly shape.

Close up image of the foreskin unfolded with the four major structures labeled in red with detailed texture.
Segment illustrating the outer foreskin structure, texture and location in context of the overall foreskin anatomy.


The Outer Foreskin

The outer foreskin is an essential continuation of the shaft skin. It keeps the glans penis protected and sensitive so it is ever-ready to respond to stimuli. It facilitates intercourse by mitigating friction and acting mechanically as a roller-gliding bearing which retains sexual fluids and helps prevents painful intercourse.

Segment illustrating the inner foreskin structure, texture and location in context of the overall foreskin anatomy.


The Inner Foreskin

The inner foreskin is smooth mucosal tissue, much like the inside of your mouth. The inner foreskin is packed with nerve endings and is designed to stimulate the glans penis while feeling slight variations in pressure and stretching, subtle variations in temperature, and fine gradations in texture.

Segment illustrating the ridged band structure, texture and location in context of the overall foreskin anatomy.


The Ridged Band

The ridged band (sometimes called the “frenar band”) is a primary erogenous zone on the male body. This unique, highly specialized, and exquisitely sensitive structure is equipped with soft ridges designed by nature to stimulate the female’s inner labia and G-spot during intercourse. Ribbed condoms attempt to mimic this unique structure.

Segment illustrating the frenulum structure, texture and location in context of the overall foreskin anatomy. 


The Frenulum

The frenulum, another primary erogenous zone on the male body, is a highly sensitive V-shaped tethering structure on the underside of the head of the penis. The frenulum connects the ridged band to the glans penis. It contains vascular structures and extreme innervation. The highly sensitive frenulum is often referenced in sexual health culture, but is almost always removed in circumcision.

Understanding the Foreskin's Complexity and Shape
A cross-sectional image of the foreskin showing its bi-layer properties, vascularization, and nerve endings.Depiction of the foreskin starting unfolded, with steps showing how it’s folded up around the penis.
The unfolded foreskin’s butterfly shape and bi-layer nature are clarified in the photos above. The sequence begins with a circumcised penis and unfolded foreskin and ends with an intact one, as designed by nature.

Folding the HuFo

What Foregen is trying to give back to you


What does it do?

The foreskin is a purposeful, integral part of a man’s body. As designed by nature, the foreskin serves six distinct functions.


The foreskin fully covers the glans, or head, of the flaccid penis, protecting it from harsh rubbing against clothing and damage while maintaining sensitivity.

Sexual Activity

The foreskin maintains interactive contact with the sensitive glans during sexual activity and provides direct stimulation.


The mucous membrane of the foreskin provides an environment that lubricates the glans to enhance sensitivity.

Sexual Sensation

Much sexual pleasure is derived directly from the foreskin, as it contains the highest concentration of nerve endings on the penis.

Immune System

The foreskin secretes anti-bacterial agents, including Langerhans cells, which can help destroy HIV as well as keep the glans clean.

Skin Gliding

The foreskin facilitates the necessary gliding and expansion of skin on the penile shaft and glans, providing for natural sensations and retaining lubricating fluids during intercourse.

Foregen's goal is full regeneration of the foreskin.


Why does it matter?

The foreskin: regaining sensitivity, pleasure, and function.

Regenerating the foreskin has two main aims:

•To reverse the harm done by circumcision.

•To bring back the sexual sensitivity, normal function, bodily completeness and psychological well-being of the healthy adult male that wishes to have his foreskin back, allowing the once-circumcised man to function normally in sexual intercourse (and in daily life) as nature intended.

No human foreskin has ever been regenerated by medical science. At best, foreskin restoration therapies can stretch the normal shaft skin left after circumcision to mimic the effect of a foreskin (known as “restoring”) but this never replaces the unique properties and functions of the real foreskin with which every baby boy is born.

Foregen is dedicated to changing that. Foregen’s mission is to harness regenerative biomedical knowledge and tissue engineering techniques to genital reconstruction for circumcised men, and to produce a therapy which will bring back the original tissue, function, and structure ablated by circumcision. Only when true foreskin regeneration is possible can the harms done by circumcision be reversed – and the benefits of being intact regained.

HuFo: The Human Foreskin

In this video, Foregen’s founder, Vincenzo Aiello, explains his highly detailed sculpture of the human foreskin and its representation of what is lost to circumcision.  With the sculpture he created, he shows the shape of the foreskin and how it attaches to the penis, along with explaining its anatomy and the role it plays in terms of sexual pleasure, protection, and more.

The benefits of an inner foreskin.

Regenerating the foreskin will increase the sensitivity of the glans, given that it will be covered and protected by the inner foreskin - a mucous membrane that prevents the glans from external abrasion.

Our procedure would lead to dekeratinization, a process whereby the layers of cells that developed (or keratinized) to protect the sensitive surface of the glans from outside abrasion is reversed. This causes the tissues normally covered by the foreskin, namely the glans penis, to become more sensitive to touch, providing for superior lubrication and a natural appearance.

A bi-layer tissue and a natural appearance.

The foreskin’s bi-layer tissue - inner and outer foreskin - would also be restored, giving men a greater surface area of skin on their penis (with a large number of nerve endings), part or all of the frenulum, the mucosal lining of the inner foreskin, and thus more pleasure. This would also serve to help men retain sensitivity as they age, as well as help older men regain sensitivity.

Foregen’s planned procedure would help to restore the natural look of the penis, keep the glans in its proper environment, and remove scarring that accompanies circumcision. Foregen’s procedure may also have a significant application for the many victims of botched circumcisions.

Sexual pleasure restored.

During sex the foreskin would provide a man with the feeling of all the nerve endings, as well as a very sensitive glans that is only exposed to touch during sex. Secondly, the presence of a foreskin allows for the abundant skin present along the shaft to glide onto the glans, providing its own stimulation and retention of natural lubricating fluids.

The stretching and relaxing of the foreskin and frenulum as the skin of the penis is pushed forward and back during intercourse is also another source of pleasure that is provided by the foreskin. The foreskin and its substructures are a major component of the pleasure and ejaculatory response in intact males.

Finally, when a man is not sexually active, the foreskin will cover the glans again, protecting it and preserving its sensitive state.

Sign up to be considered for clinical trials