Eric Clopper

  • commented on Foregen Presents at The World Stem Cell Summit 2017-06-05 09:43:15 -0400
    Hi Jack,

    Thanks for sharing your comments. We agree that Foregen addresses a huge and obvious problem that will do well once this problem is acknowledged, but we have not reached that level of awareness yet in our culture.

    We’ve been able to make partnerships with some of the industry’s leaders in regenerative medicine – this is no small feat considering we are challenging and changing the US’s genital cutting culture. But, until we have peer-reviewed published research, which we are working on now, professional investors cannot touch us because they have their own reputations to protect and they see us as too risky.

    I encourage you to recruit the CEO of Mozilla to our management team; we would love to have him.

    Eric

  • commented on Update from the Foregen Labs on our Human Tissue Experiments: August 2016 2016-09-18 13:50:59 -0400
    We love to see your guys’ support. Thank you so much for being a part of our success.

    Our next update will likely be in October, but maybe November. We are making progress towards our first publication on human tissue, so no worries there.

  • donated 2016-06-28 14:14:27 -0400

  • commented on Foregen Pitch at Draper University 2016-05-02 11:36:52 -0400
    Thanks Andreas!

  • published Supporter Outreach and Human Tissue Experiments in Blog 2016-04-11 19:46:38 -0400

    Supporter Outreach and Human Tissue Experiments

     

    Over the last few months, we’ve been busily working away at our plans to accelerate our progress towards the goal of regrowing foreskin through tissue regeneration. You will be pleased to know that we have everything in place and are about to start our first experiments on human tissue, a critical first step before we can move on to human clinical trials. More updates on this will follow soon.

    Additionally, we’ve started early negotiations with professional investors, with the ultimate goal of acquiring sufficient funds to form a new for-profit organization. These partnerships will bring our planned foreskin regrowth procedure to our supporters around the world and to the public at large.

    In the meantime, we’ve been conducting our biggest outreach effort to date. We’re contacting all of our existing supporters in order to figure out what we do well, what we could do better, and to directly answer any questions that you have.

    Read more

  • commented on Funding Foregen 2016-04-04 13:44:46 -0400
    To answer your question Tim, to be a “professional investor” you need to be an accredited investor, which just means you have a certain net worth and income. As an early investor, and part owner of the company, perks may come with that beyond just the potential to make a large return on your initial investment.
    Andrzej, using a donor’s extracellular matrix does not use their DNA. These ECMs will act as the scaffolding for the patient’s cells to populate. That doesn’t preclude us from exploring other options that are more amenable to mass production down the line.

  • published World Stem Cell Summit Recap in Blog 2016-03-08 16:51:31 -0500

    World Stem Cell Summit Recap

    I’ve been meaning to write a recap from the World Stem Cell Summit for quite some time now; it has been too long since my last blog post. We’ve been very busy in the interim. Personally I’ve been in Silicon Valley at an entrepreneur accelerator called Draper University building a great network for future funding opportunities. Now that I’m back working with Foregen full-time, expect far more regular updates.

    Read more

  • commented on Video Update from Chinese-American Investment Video: XTecher 2016-03-07 01:06:02 -0500
    Thanks Vincent! We’ve made a lot of progress recently. I’ll be updating the blog weekly/bi-weekly from here on out with our developments.

  • Foregen to be in the upcoming Intactivist Documentary & Crowdfunding Campaign: Pigs Without Blankets

    In the middle of last year I had reached out to the producers of a successful Kickstarter called Pigs Without Blankets. The premise of this Kickstarter was to create a PSA to describe what the foreskin actually is, i.e. a normal part of the male's sexual anatomy, in a somewhat humorous way to start a dialogue about circumcision.

    If you watch the video in this link, Kenny Shults, the star, is actually quite funny, even with such an unfunny topic. 

    Read more

  • published Foregen in San Fran and Toronto Pride in Blog 2015-07-06 09:33:11 -0400

    Foregen in San Fran and Toronto Pride

    Foregen at San Francisco Pride

    By Peter Benson Foregen_booth.jpg

    Life changing is the only way to describe our Foregen booth experience at SF PRIDE. Celebrating the recent Supreme Court victory, the city was buzzing with a vitality reinforced by the notion that anything is possible. After all, that is why Foregen is here. We seek to open doors previously sealed with permanence and give people back a greater sense of self-dignity, choice, and satisfaction. Likewise, the limitlessness derived from medical regeneration was the most consistent point of amazement for passersby, especially as it pertains to the body part most culturally synonymous with irreversibility, the Foreskin. Our task was to bring people to the booth, showing them that together we can achieve the impossible.

     

    Read more

  • published Damien's Story in Supporters' Stories 2015-04-12 10:35:00 -0400

    Damien's Story

    Hello everyone i would like you to get to know me a bit better. My name is Damien A Robinson, and i was circumcised as an infant, (neo-natal circumcision), So this kinda struck me one day on wondering why some of the penises i saw had skin on them, so i learned that it was called foreskin (i was 16 at the time when i discovered that) and i was wondering what it would have felt like if i had that skin, so i got upset at my parents for having it done to me, they told me it was cleaner (which is a myth) and that i wouldn’t lose any sexual pleasure (which is also not true) i noticed that my skin on my penis became very dry and not too sensitive, i was not happy at all.

    In-fact i was so upset that i lost hope getting my foreskin back since i did the research, half a year after my 18th birthday i found out about foregen though foreskin restoration and this popped up and i felt so happy that someone was trying this, All these babies that get circumcised scream and cry in agony why would you want to do this to your son? Why would you make him go through the pain that you went through aren’t you supposed to want better for him? But i guess not, here in the united states i’ve heard people say circumcision rates are falling due to awareness which is right ( i hope anyway).

    I want people to understand that it’s not for cleanliness, it’s taking away a natural thing that is supposed to occur and it should not be messed with or cut or sized down, Think of it like the heart, what happens if someone took a chunk away because they thought it would be cleaner? It wouldn’t work if you ask me.

    I hope the medical community realizes that its not some useless piece of skin, Most men here lost 20,000 Nerve endings that would make sex for the guys who were circumcised less pleasurable, without the foreskin that’s where all those issues come in. I would love to see this succeed, the more awareness means more backlash toward the procedure of circumcision. However for me, i’m still very upset that i had no choice, when i found that out i was just so angry i have no words to describe the pain. I felt like i was humiliated, i felt like a piece was missing all my life and i was right!

    I would love to thank this community and the search engine i used to have faith in something that would work for the greater good of humanity, i am honored to be on this website.

    This is my story.


  • published HBO's VICE Features Foregen in Blog 2015-04-12 10:22:20 -0400

    HBO's VICE Features Foregen

    Here's a throwback to our first major press mention written 2 months ago! We'll be collecting all of our media mentions from the past and all our future media events in the future and posting to our blog. Stay tuned for the complete list in the weeks to come. Read the rest:
    How One Company Aims to Help Circumcised Men Grow Their Foreskin Back


  • commented on Circumcision Myths 2015-03-23 21:29:10 -0400
    Thanks Derek! You’re absolutely right that the external biases of these studies, i.e. they were done in a completely foreign social landscape and thus not applicable to a N. American male, invalidates the claims that these studies can be simply mapped to a US population (I address this a little more thoroughly in the history section).
    Even if they could, it shouldn’t matter. What did the WHO do when reliable studies suggested that female circumcision may mitigate the risk of HIV contraction in 2005? They decried female circumcision as a human rights violation, they did not call for mass female circumcision initiatives. This double standard is painfully clear.

  • Foregen President, Vincenzo Aiello, shares recent progress and announces KickStarter!

    Foregen president, Vincenzo Aiello, gives a recap of Foregen's huge progress in 2014, touches on some of our large developments in 2015, and reveals his upcoming KickStarter! Click below to find out more:

    Enzo's February 2015 Foregen Update


  • donated 2015-01-15 13:12:36 -0500

    Donate with PayPal

    In order for us to continue research full-time to produce a regenerative therapy for circumcised males, we will need to spend about $20,000 per month for the foreseeable future.

    Here you can send a single, one-time donation to Foregen, Inc. Simply select your contribution amount on the right and the form will guide you.

    Donations made on this page do not count towards our monthly quota as this is a one-time donation. We encourage that you become a monthly donor (click here) to help us move the bar and get one step closer to becoming a full-time research organization.

    Thank you.

    We are a US registered 501(c)3, your contributions are tax deductible.

     

    Donate

  • published Michael's Story in Supporters' Stories 2015-01-12 20:52:21 -0500

    Michael's Story

    Foreskin regeneration gives me an opportunity to be uncut again. At age 13 and 9m, I was scheduled to be circumcised. I remember going online, and seeing the ramifications and what things could be excised following circumcision, but my father assured me that it was just a piece of skin. I believed him and got it done with ambivalence. When I no longer felt the pleasure, and the series of burning pains after my head would be abraded with my underwear, I noticed what a big mistake I had just made. I have my faith in these people that foreskin regeneration can become a reality, and that others who've missed out because it was done way early on or unfortunate ones like me who fell for the bait, could have a chance to gain foreskin once more


  • wants to volunteer 2015-01-12 10:12:05 -0500

    Volunteer

    Become a Volunteer!

    As we expand, were always looking for skilled and dedicated members to recruit to our workforce. If you are a doctor, an artist, a lawyer, or most importantly have a passion for the cause and want to be boots on the ground at future Foregen events, please drop us a line in the volunteer box with the skills you'd like to volunteer and we'll do our best to find you a place!

    Interested in Helping the Cause? Signup Below:

    Become a volunteer

  • signed up on Human Clinical Trials 2015-01-12 13:46:35 -0500

    Participate in Clinical Trials

    Human Clinical Trial

    Hand raised

    Foregen's major objective is to fund a clinical trial of foreskin regeneration in the circumcised adult male.

    The Background

    Medical research has made true dermal regeneration possible to a greater extent than ever before (for more on the science side of things, see our page on The Science of Regeneration). However, foreskin regeneration has not yet been tried, despite our knowledge that foreskin fibroblasts respond extremely well to regenerative technologies which create new skin. Foregen believes that it is time such a trial was undertaken.

    What kind of trial?

    Foregen will conduct a trial to reattach regenerated foreskins to circumcised adult males to restore the vascularity, nerve endings, and function that are excised during circumcision.

    How will we get there?

    Foregen's road map towards our ultimate goal of male foreskin regeneration is as follows:

    1. We will raise funds
    2. We will use our scientific panel to find the facility and recruit the researchers who are most likely to perform research which will lead to a clinical trial
    3. We will complete any necessary laboratory and pilot research and publish these results in a peer-reviewed journal
    4. Finally, we will carry out a clinical trial

    We are currently on step 3 of our journey

    Step 3 consists of fully regenerating animal foreskins and then conducting the same experiments on human foreskin. These results will be published in a peer-reviewed journal.

    Of course, this road map is a simplification. There are complexities and uncertainties in such a trial as there are in any clinical trial that pioneers something new. Foregen cannot guarantee the final outcome or predict unforeseen obstacles that may fall in our way. However, Foregen recognizes the need for such a trial. We know how much success dermal regeneration has had in other areas, so we have good reason to believe that it will succeed in ours. While the outcome is not, and cannot, be certain, it is clear that we must try.

    Interested in Participating? Read below...

    The trials will be controlled and have the proper governmental approval. The trials will not be conducted by Foregen personnel, but rather by medical professionals adhering to the highest ethical standards of practice and research.

    Currently we are actively recruiting trial participants who are:

    • Males over the age of 18
    • Circumcised, but not otherwise suffering from other health problems

    A clinical trial is estimated to take up to eight weeks, though not all of that period will be spent under medical supervision.  If you satisfy the above requirements and are interested in volunteering for this trial, we would be happy to hear from you. All medical care will be provided free of charge and you will be able to withdraw from the trial at any stage.

    Volunteering for this clinical trial makes you eligible to benefit first from the most advanced medical technologies available for foreskin regeneration.  However, such participation, like all medical procedures, carries some risk. The medical professionals conducting the trial will discuss with you the full range of options, possibilities, and dangers in order to assess your suitability for a trial. They will also, of course, need to obtain your full informed consent to participate in the trial.
    Any person who indicates an interest is not under any obligation if you lose interest, you will be removed from our list of potential participants upon request. (But we don’t think you’ll want to!) 

    Still Interested? Create an account and signup below!

    * Please note, this does not enroll you in future clinical trials, it simply ensures you receive relavent information regarding those trials as it becomes available.

    Sign up

  • published Randy in Supporters' Stories 2015-01-02 22:38:42 -0500

    Randy's Story

    Being born in 1958 I was circumcised at birth, my father being born in the 30's was uncut. As a child, seeing my fathers penis fully covered and then others my age fully exposed it naturally occurred to me that the difference was a matter of growth. Yes, as a child I thought that the skin would naturally grow to cover my head so that my penis would eventually look just like my dads. With age came the shock and disappointment I still experience today.


  • published FAQs 2015-01-02 00:12:35 -0500

    FAQs

    Foregen FAQs

    We receive questions daily from our supporters as to the availability of foreskin regeneration and the time frame of when we will complete our research and move on to human clinical trials. In these early stages of research, it is impossible to answer all of these questions fully. That being said, we base our answers off of previous achievements in the field of regenerative medicine and our best approximations based off of our current information.

     

     Updated 2/7/18

     

    1.) What is Foregen's goal?

     

    FULL regeneration of the foreskin, with all its neural infrastructure. For more info on this, see here.

     

    2.) What will the expected procedure consist of?

     

    As we get closer to clinical trials and ultimately complete them, we will, of course, have more details for you. For now, the following is a good description of what it should be:

    Our process right now consists of decellularizing the adult donor foreskin, which means we strip away the cells until only an Extracellular Matrix (ECM) is left. This ECM is then reseeded with your own stem cells to regrow and regenerate the structures of the foreskin.

    The surgeon will reopen the scar line then attach the foreskin via microsurgery and apply stem cells so that the current scar line is healed and there would be no additional scars. Additionally, because the skin is decellularized, once it integrates itself, your DNA will take the foreskin’s place. Out with the old, in with the new. That means that the foreskin will truly be yours, how it would have looked and all the parts and pieces just as it would be if you had never been circumcised.

    Chances are, it won't even look like the donor after all is said and done because your cells will have grown anew and the old will have died off. The same process happens with all cells throughout the body.

    Initially, it will be a donor foreskin from a cadaver. Once our procedure is commercially available in the future, we will also be working toward a 3D printing system, which is currently used for certain regenerative methods. This would be printed with the patient's DNA and properly innervated, along with the other structures of the foreskin to create a custom regenerated foreskin.

     

    3.) How will the ridged band and frenulum be regenerated and attached? Will all the foreskin be regenerated and be completely functional? What about different sizes of remaining frenulum?

     

    Yes, our goal is to regenerate all the structures and restore full functionality. The ridged band is part of the Extracellular Matrix (ECM) and will be regenerated alongside the other structures. The frenulum is also taken from the donor during the collection process and will be regenerated as well. Regardless of if you have a frenulum left or not, or one that is of different size, we will make sure it is regenerated and reattached.

     

    4.) Some people claim that nerves atrophy over time due to a lack of stimulation. Will all the neurons and pathways responsible for the foreskin's erogenous response register with the new foreskin? For example, will the brains of men circumcised as infants be able to register their regenerated foreskin as if they had never been circumcised?

     

    Even when circumcised, the remaining foreskin still sends all the information through the very same spinal neurons. While we might have tens of thousands of nerve endings, they all lead towards the same big channel(s) leading into the spine and finally to the brain. If your whole penis was removed at birth, then there might be cause for concern. But this way, the axons in your spine associated with your foreskin have always been used because they are used for the entire penis. We also know the brain can receive sensation from newly transplanted limbs. We've never seen how the brain reacts after receiving a foreskin post-circumcision because it has never been done - that is our goal, and we are confident it will be a success.

     

    5.) Can the regenerated foreskin be adjusted to any penis size?

     

    Yes, both the cadaver (donor tissue) and the 3D printing methods will achieve a foreskin adjusted to every patient.

     

    6.) Will there be a scar where the new foreskin is attached?

     

    There shouldn’t be a scar after the procedure because stem cells will be applied to the site of the surgery and should prevent scarring from occurring.

     

    7.) What about phimosis? Or if I've had it before?

     

    Foregen will make sure that each foreskin is custom fitted to the patient. Phimosis is not genetic but rather caused by some form of scarring (from the foreskin being forcibly retracted, for example). It should not reappear after Foregen's procedure. Furthermore, there are other ways to handle phimosis other than circumcision, so even if phimosis somehow occurred you won't necessarily require circumcision.

     

    8.) How far has Foregen progressed in its research so far?

     

    Right now Foregen has successfully completed the decellularization of both animal and human foreskins, most recently the human ones. We will be publishing and patenting the techniques used in these experiments. We will then move on to the next phase of our research, which will consist of animal trials to test the safety and efficacy of the decellularized foreskins. Depending on the results of those experiments, we will then work on recellularizing (regenerating) them. Foregen's push forward in research, of course, depends on supporter contributions.

     

    9.) Where does the donor foreskin actually come from? Will I get a dead guy’s foreskin?

     

    The donor foreskin is taken from a consenting, deceased adult male. However, it will not be a ‘dead guy’s foreskin’. The donor foreskin will undergo a process called decellularization that strips the foreskin of the donor’s cells and DNA, which reduces it to an Extracellular Matrix (ECM). This ECM is then seeded with your own stem cells to regenerate the structures of the foreskin, which means the foreskin will be truly yours.

     

    10.) Your website often shows that you fall short of monthly donation goals. What will this mean for us? Delays? Postponement?

     

    The $20,000 goal is to conduct our research full time, not reaching that goal means we won’t be able to hire our researchers full time, but with the expected change to for-profit this year, we should be able to start conducting full-time research soon. Also, conducting research in Italy is less expensive than it would be in comparison to the U.S., which enables us to maximize the utility of our current budget.

     

    11.) How far away are we from conducting clinical trials?

     

    Clinical trials are expected to start in 2019 granted we hit all our funding goals and research milestones in the interim.

     

    12.) Will I have to go abroad to get the procedure or will it be available elsewhere?

     

    Since our research is currently being conducted in Italy, that is likely where our procedure will be first available. However, since we know there will be demand around the world for our procedure, we will seek to expand where we offer it and make sure the proper approval is received.

     

    13.) Will there be a big enough supply of donor foreskins before the 3D printing is available?

     

    Due to the scarcity of the donor tissue, there will be a bit of a wait time, but we will try to get our supporters in first. Also as time goes on, we’ll be able to get more and more tissue from different countries around the world, given that most countries leave males intact. This means more opportunities to receive tissue from donors.

     

    14.) Will the penis need to stay flaccid for a period of time after the procedure while everything heals and how will this be achieved?

     

    Yes, the penis will need to stay flaccid for some time after the procedure in order to properly heal. There are medications that can be prescribed to prevent erections and therefore ensure full healing.

     

    15.) How will stem cells be extracted from the patient?

     

    At the moment there are several different methods we could potentially use, one of them being the patient’s blood to extract the stem cells.

     

    16.) Does signing up for the clinical trials early increase your chances of getting in?

     

    While it does register you as interested, it only means that we could potentially select you for the clinical trials. Acceptance will depend on age, health, and other reasons. We are not yet at a point to give a full list of requirements.

     

    17.) So, since it’s all about research (and its funding), what kind of research is Foregen actually doing and how can you be so sure that it’s doable?

     

    The very short answer: similar stuff has already been successfully done, and therefore Foregen's task doesn’t require a lot of pioneering work, but only the application of already existing technology.

    The long answer: The keywords are regenerative medicine, stem cells, and stem cell medicine. Regenerative medicine is an umbrella term for all the medical disciplines that aim to restore functions in the human body that were lost completely either through injury, disease, age etc. One of the most promising disciplines in this important field of medicine is so-called "stem cell medicine“. In a nutshell, stem cell medicine uses stem cells to regenerate functional human tissues and organs. These can then be used as replacement parts for damaged or defective structures in the patient’s body.

    Having explained this, why is Foregen so sure that they will fully regenerate the human foreskin? The answer lies in the past 10 years. Stem cell medicine has existed roughly since the discovery of stem cells in the 60’s and 70’s, and it has come a long way until it’s reached the level of expertise it has today. Through the successful research of some key components, stem cell medicine has enabled the creation of all kinds of tissues and organs in the recent past. You can find a comprehensive list of confirmed successful applications here. One very important, more recent achievement from 2015 has been the creation of full-thickness human skin. Full-thickness skin means skin that contains both the epidermal and the dermal layer. The epidermal layer is the ulterior protective barrier of the skin, while the dermal layer contains all of the infrastructure: Blood vessels, neural structures, hair follicles, sweat glands, and so on.

    How exactly this stuff is done would take even longer to explain, but the above-posted link to Foregen's website gives a good overview of the basics. What should be clear by now is that Foregen doesn’t have to explore uncharted fields of science for this. Much more complex organs of the human body have already been successfully targeted, and although it will cost time and money to do the foreskin, it is absolutely doable within a reasonable time frame.

    Below are some more links to reports about more recent successes in stem cell medicine:

    The following quote is also taken from an article on Foregen from the UK Mirror in 2015:

    ”Dr. John Barker from the Frankfurt Initiative for Regenerative Medicine told Mirror Online that Foregen's ambition sounds plausible. Foreskin is already widely used to harvest skin cells for a variety of scientific applications, he explains, “so it would be fairly easy to adapt” the process for Foregen's purposes. He points out that similar tissue has already been engineered in the lab to make bladders, penis tissue, urethras and vaginas. Barker says it’s easy to generate the scaffold and harvest the skin cells, but the difficult part is the transplantation of the newly grown foreskin to the desired location. Getting the blood supply in place “could be tricky but doable”.”

     

    18.) Now that I know everything about the science behind it, what about the economics. You need money to continue research, but how will that be settled? How are you funded? Most projects like this receive government funding.

     

    Foregen is currently reliant on donations from our supporters. If you are interested, see this link for details: https://foregen.nationbuilder.com/donate

    You can also follow this link for more details on our monthly expenses to understand where our donations go: https://foregen.nationbuilder.com/get_involved

     

    Foregen’s spokesman, Eric Clopper, explained at the WSCS (World Stem Cell Summit) what Foregen wants to do and why, and he also presented them Foregen’s business plan. In short, it’s a 5 year, 5 phase business plan that consists of 3 financing rounds through which the research is funded. 

     

    19.) Does Foregen have the personnel to conduct the research?

     

    Yes, Foregen has skilled scientists currently working on research. Dr. Elena Bondioli has over 10 years of experience in the field of skin regeneration, along with Dr. Valeria Purpura, who is also skilled in the field of regenerative medicine. Foregen will also look to hire more scientists and researchers as time goes on.

     

    20.) Considering Foregen’s current status, what are the short and mid-term plans to cope with the current funding problem?

     

    First, Foregen aims to transition to a for-profit organization in 2018. Through this Foregen aims to attract potent investors, who will help to fund the next phases of its research. However, Foregen is also simultaneously promoting itself through appearances in the public, medical conferences, awareness campaigns like HUFO (which was successfully funded in April 2015), and Pigs Without Blankets, a satiric documentary about circumcision culture in the US and Foregen’s role in coping with its consequences. We've also teamed up with Brendon Marotta, director of the award-winning film, American Circumcision.

     

    We will look to publish two papers this year (2018): one on animal and one on human foreskin decellularization. Building off of that momentum, we will look to raise a large round of financing via equity investors once we’ve proven our ability to perform such a high level of scientific work. We’ve made strategic partnerships with life science brokers in New York City and crowdfunders in Boston and are looking forward to announcing our next big step in the process once we are legally able to do so (SEC and FINRA regulations prevent us from making certain forward-looking statements and we have no desire to become entangled in an unnecessary lawsuit with the federal government).

     

    21.) How much will the procedure cost and will insurance be able to cover part of it?

     

    Right now, we’re estimating about $10,000 total for the operation. However, we also want to have payment plans available to make the procedure more accessible. In terms of insurance, it will largely depend on the country and the culture. The more pro-circumcision a culture is the less likely it will be covered by insurance. Of course, a culture can change over time, and with changing views might come a willingness by insurance to cover the procedure. This is speculation so we can’t guarantee any of this will happen, but it’s something to keep in mind. Furthermore, the cost of the procedure, like other regenerative medicines, is likely to decrease over time:

    http://stemcellassays.com/2015/11/manufacturing-cost-of-bioengineered-organ-the-first-analysis/  

     

    22.) Will a restored foreskin interfere with the surgery?

     

    We can’t say 100% right now how restoration will affect our procedure. It may just be a simple matter of removing the restored foreskin and reattaching the regenerated one. However, rest assured that if we need to create a procedure specifically tailored to restored or restoring men we will do so. We know there are many men who are currently restored or restoring so we want to make sure they can access the benefits of our procedure too.

    It is also worth noting that neither Eric Clopper nor Vincenzo Aiello (spokesman and founder) are restoring. Both have stopped and are waiting for the technology to become available.

     

    23.) How can Foregen regenerate nerves?

     

    Regenerative medicine and the regeneration of nerves is a complex science. For a cursory understanding, the nerves are regenerated when the Extracellular Matrix is reseeded with stems cells converted from your cells, along with the foreskin’s tissue. For a more comprehensive understanding beyond the layman’s standard please consult this thesis titled Regeneration of Peripheral Nerves Using Neuroinductive Biomaterial Scaffolds by Paulina Sierpinski Hill. A PDF of this thesis can be downloaded from our site: Regeneration of Peripheral Nerves Using Neuroinductive Biomaterial Scaffolds

     

    24.) Even if they regenerate nerves how will the recipient be able to feel them? How will the nerve endings link to the brain, and how can they be connected to the penis?

     

    In other regenerative medicine projects, the nerves have been successfully regenerated, reattached and the recipient has gained full sensation. For instance, researchers grew vaginas in labs and implanted them in patients who were born with a rare genetic condition in which the vagina and uterus are underdeveloped or absent. In this case, the regenerated vaginas did integrate perfectly with women who were not even born with them. They went on to even report orgasm. Foregen is carrying out similar procedures for men’s foreskins.

     

    https://www.livescience.com/44756-lab-grown-vagina-implants.html

    https://www.youtube.com/watch?v=IHF-lIu5D_U

     

    25.) What about cancer? Regenerative tissue has the potential to become cancerous.

     

    The risk of cancer in the regenerated foreskin is extremely low. There have been numerous examples of patients with implanted regenerated organs, parts of organs, and tissues dating back almost twenty years and have not reported cancer. The earliest transplant of a regenerated and implanted organ or tissue was in 1998. There have been other successes since then and no reported cancer.

     

    http://www.wakehealth.edu/News-Releases/2006/Wake_Forest_Physician_Reports_First_Human_Recipients_of_Laboratory-Grown_Organs.htm

    https://www.livescience.com/44756-lab-grown-vagina-implants.html

     

     

    26.) People have had their foreskin restored before in the form of plastic surgery. How is Foregen different to this?

     

    The types of surgeries you are referring to involve the use of skin from another part of the body to create faux foreskin. This faux foreskin covers the head of the penis but lacks any of the unique properties of the foreskin, such as the ridged band, frenulum and inner foreskin mucosa. Furthermore, this plastic surgery does not regenerate nerves and the receiver cannot feel sensation in this faux foreskin.

     

    Foregen is fundamentally different to this plastic surgery and should not be compared. Foregen is using regenerative medicine and stem cells to regenerate the whole of the foreskin and its unique properties, such as the frenulum, ridged band and inner foreskin mucosa. This is akin to how a salamander regenerates a lost limb. Foregen also seeks the regeneration of nerves and thus full sensation in the regenerated tissue.

     

     

    27.) Will this involve more surgery? I don't want to have more surgery.

     

    Yes, the procedure will involve surgery. Donor foreskins are decellularized, stripping them of donor cells and DNA, reducing them to an Extracellular Matrix. This is then reseeded with stems cells converted from your cells, regenerating the foreskin's structures. This is then attached to your penis at the scar line via microsurgery attaching all of the structures involved including nerves and blood vessels.

    However, it is important to understand that such a procedure will fix your ailment; as opposed to circumcision which removes healthy tissue and damages the penis. Also, Foregen will employ skilled microsurgeons to carry out this procedure. Foregen’s use of stem cells will help minimize or reduce entirely scarring where the foreskin is reattached. 

     

     

    28.) How can Foregen define itself as a biomedical company? Aren't you just a commercial interest? Are you a tissue manufacturer? Do you employ people, or do you just have contacts with researchers?

     

    Foregen is a biomedical startup that is researching the regeneration of the male foreskin. Currently, two researchers are employed through contracts. Dr. Elena Bondioli has over 10 years of experience in the field of skin regeneration, along with Dr. Valeria Purpura, who is also skilled in the field of regenerative medicine. Foregen will also look to hire more scientists and researchers as funds increase.

     

    29.) How can I help Foregen reach their goal?

    There are a variety of ways in which supporters can help us achieve our goals. The most direct way to help Foregen is to subscribe as a donating member. This allows us to plan ahead and continue our research, networking, and self-promotion. If you can’t donate, spreading the word helps significantly. Sharing our posts, videos, and news with other people and even making sure other intactivists are aware of our organization is an important step towards completing our goal. You may also consider volunteering. Please see our latest newsletter found on our website's blog to see open positions.

     


Featured Publications

  • The Good Men Project
  • Motherboard at Vice.com
  • Men's Health
  • The Telegraph
  • Towleroad

Translate Site

Contact Us

Foregen
P.O. Box 570076
Dallas, TX 75357
Circumcision penis foreskin
Foregen Italy
Via campi flegrei 59,
00141 Rome, Italy